Green pathway

(A) Genes upregulated only in the Un treated group compared to the healthy control group. (B) Genes up/downregulated only in the ART group compared to the healthy control group. Red or green borders in the bar graphs represent upregulation or downregulation respectively compared to the control group. Figure 6. Gene expression changes in the basal ganglia found exclusively in either the Untreated group or the ART group, compared to the healthy control. (A) Genes upregulated only in the Un treated group compared to the healthy control group. (B) Genes up/downregulated only in the ART group compared to the healthy control group. Red or green borders in the bar graphs represent upregulation or downregulation respectively compared to the control group. Figure 7. Biological Functional Annotations in Untreated vs. ART. DEGs in the ART and the untreated groups were analyzed. Differential pro-inflammatory functions were enriched for each group. The activation and inhibition of functions are shown by orange and blue colors, respectively. DEGs were defined by fold change > 2 and p Figure 7. Biological Functional Annotations in Untreated vs. ART. DEGs in the ART and the untreated groups were analyzed. Differential pro-inflammatory functions were enriched for each group. The activation and inhibition of functions are shown by orange and blue colors, respectively. DEGs were defined by fold change > 2 and p Figure 8. ART vs. Untreated Pathway Analyses. (A) Canonical pathways enrichment analysis. The red box highlights the discrepant pathway between groups. (B) Expression of genes in the osteoarthritis pathway. (C) Regulator Effects network in the untreated group. It illustrates the relationships between the upstream regulator (OSM) and downstream function and diseases (damage of cartilage tissue). The measured and predicted activation is represented by the red and orange colors, respectively. Figure 8. ART vs. Untreated Pathway Analyses. (A) Canonical pathways

Childhood and adolescence, personal TSA system remains powerful and effective. When a child senses that something is threatening, the calm, exploratory, “green” pathway of his brain (known as the social engagement system) veers onto the red pathway that is designed to keep him safe. The result: challenging behaviors, tantrums, meltdowns, and even aggression. When a child senses danger, his brain and body respond with protective “fight-or-flight” behaviors. That’s right, fight or flight behaviors are biologically protective.Sometimes a child’s brain and body registers threats that might be invisible to a parent. Anything can set off the threat-detection system. A child might have a meltdown at the grocery store because his body is tired. Another child might experience sudden separation anxiety after being dropped off at school and as a result, kick a peer in the shin. This doesn’t necessarily mean that something is “wrong” with the child. It simply means that the child’s emotional resilience is fragile in that moment and/or still developing.Fatigue, anxiety, feeling unsafe or unwell—any of millions of invisible triggers can send a child onto the red pathway of explosive behaviors. When this happens, it’s important to remember that the child is not choosing the behavior, but rather the child’s autonomic nervous system is choosing it. In short, a tantrum is rarely a conscious choice.If children didn’t have the fight or flight pathway as a way to manage perceived threat, they would have one alternative when they sensed danger: to freeze or shut down. It’s important to remember that a child who freezes or shuts down in response to any situation is in autonomic-nervous-system distress and needs immediate, supportive intervention.The bottom line: meltdowns and tantrums are not purposeful misbehavior. That’s why it’s important to not punish or offer negative consequences for such behaviors. In the moment, a child

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