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You actually need to use physical attacks, since you do not have Senho. Shiga is well-balanced and suited for this easy SurvivalMode. -Stage 1-Rune equipment: Fusenso and JitsugetsuDirect Lv5 Mistral (from Fusenso)Target Lv5 Cyclone (from Fusenso)Sword Lv1 Windblade (standard)Jump Lv1 Storm (from Jitsugetsu)Added Bonus from runes: RA+4Reason: You will be fighting close up in Beginner Survival Mode, and there isno faster and more protective Direct spell than Mistral. Cyclone is excellentfor targeting groups, and Storm is good for the RJ tactic. Walkthrough: Although you will have to periodically stop to charge, use the RJsystem to fend off the dogs. Mistral in a combo should also knock the dogs farand protect you. Once the area is clear, take the shortcut path, NOT THE PATHTHAT PASSES BY THE SMALL LAKE. This way, you fight less enemies. Continue usingRJ on the enemies you run into on the way to the Bruin. When you reach the areaof the Bruin, DO NOT jump down. First, snipe out the enemies near the Bruinusing Cyclone. Afterwards, jump down and destroy the archers that appear witha few Storms. Now, the Bruin should be by itself. Use Target magic and keep hitting the Bruin until it dies.-Stage 2-Rune Equipment: Same as Stage 1.Walkthrough: Mainly use Cyclone for this battle. Use it to quickly break apartsmall groups of enemies. Be careful not to get in a spot where the cannons canhit you. Target small groups of enemies at a time, so you only have to dealwith a small group of enemies. This is a simple stage, thanks to the lack ofbosses.-Stage 3-Rune Equipment: Gokuseki and Inyo+2Direct Lv2 Bolt (from Gokuseki)Target Lv3 Lightning+1 (from Gokuseki)Sword Lv3 Windblade+2 (from Inyo+2)Jump Lv1 Storm (from Gokuseki)Added Bonus from runes: Health +50Reason: You want to snipe enemies from far away in this stage, so Cyclone andMistral will not work. This rune combination gives extra health AND Lightning+1and Windblade+2. You need this Target Spell to shoot enemies from far away andWindblade+2 to attack Karas.Walkthrough: From the beginning, snipe out all enemies you can reach with your Target spell. When all the enemies you can hit are

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Dead, go along the west sideof the stage. From a certain point, you can snipe Karas for a while. Karas hasa high rune defense, so it may be a good idea to go down where Karas is and usethe RJ tactic, except use sword magic (like holding down square) instead. Karas drops a lot of health, so once he dies, use Target magic on Kresh. Hewill come to you, so continue using RJ tactics and use Jump magic this time. These bosses are unusually strong, but have patience, and they will die. -Stage 4-Rune Equipment: Same as Stage 3.Walkthrough: You will fight 3 sub-bosses. The room is nice and long, so keeprunning along the walls. The bosses are slow wlakers, so it will take them sometime to reach you. This gives you a chance to charge your magic bar. When youare ready, attack the bosses with Storm. In time, if this is done over and over, the bosses will die. Remember, do not fight up close; Jump magic is theeasy way to win this stage.-[Intermediate]----------------------------------------------------------------My character of choice: TaiReason: The stages in intermediate are LONG AND BIG, perfect for sniping. Therefore, you need magic power, not speed. Tai is an excellent choice.-Stage 1-Rune Equipment: Gokuseki and SenhoDirect Lv2 Bolt (from Gokuseki)Target Lv3 Lightning+1 (from Gokuseki)Sword Lv1 Thunderblade (from Senho)Jump Lv1 Storm (from Gokuseki)Added bonus from runes: Magic RestoreReason: This combination is INCREDIBLE. The Lightning+1, Storm, and magic restore is all that is really needed. Walkthrough: From the beginning, use the RJ tactic, but stay around where youare. You do not want to disturb the plant enemies ahead. Once the dogs are deadsnipe Lightning+1 spells at the plants. Slowly make your way towards the Bruin,sniping enemies first, then using the RJ strategy. Once you make it to the Bruin, use Target spells to kill the Bruin. Continue on through the stage always rolling and using jump magic. Eventually, you will reach the two Juggaurnauts. Use RJ on the two bosses, and use Target magic whenever possible. -Stage 2-Rune Equipment: Same as Stage 1.Walkthrough: From the beginning, you are surrounded. But if

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Of Newton, Illinois. His mother-in-law, Connie Kerner of Newton, Illinois, and his father-in-law Jim Kerner of Newton, Illinois. His sister in-law, Cassie (Darrin) Campton of Dieterich, Illinois, and brother-in-law, Jay (Julie) Kerner of Teutopolis, Illinois. Three grandchildren will cherish his memory; Crew Esch of St. Louis, Missouri, and Bexley and Bruin Byram of Terre Haute, Indiana. In addition, he leaves many special nieces and nephews; Meridith (Matt) Oliver, Mitchell Keller, Clayton (fiancée Nikki Miah) and Callaway Campton, Drew and Paige Kerner, Mabry and Sienna Mitchell.He is preceded in death by his father, Ed Mitchell, and his grandparents, Clyde and Marie Mitchell, and Loren and Marie Kibler.Visitation will be held on Tuesday, February 1, 2022 from 9 a.m. – 11:30 a.m. at Johnson Funeral Home in Effingham, Illinois. Funeral Services will directly follow and begin at 11:30 a.m. Burial will be in Oak Ridge Cemetery in Effingham, Illinois.Memorials may be made to the local chapter of National Alliance on Mental Illness (NAMI). Online condolences may be shared by clicking here.. De Bruin Autotechniek's post. De Bruin Autotechniek. 󰞋󱟠 De Bruin Autotechniek's post. De Bruin Autotechniek. 󰞋󱟠 󰟝

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Survival, and time to next treatment or death when compared to investigator’s choice of treatment. The trial included 238 patients with CLL/SLL who had previously received a covalent BTK inhibitor. The patients were randomly assigned to receive pirtobrutinib (n=119) or investigator’s choice of treatment (n=119), which could be idelalisib plus rituximab (n=82) or bendamustine plus rituximab (n=37). The median PFS per independent review was 14.0 months in the pirtobrutinib arm and 8.7 months in the investigator’s choice arm (hazard ratio [HR], 0.54; 95% CI, 0.39-0.75; P =.0002). The median PFS per investigator assessment was 15.3 months and 9.2 months, respectively (HR, 0.48; 95% CI, 0.34-0.67; P “The study was positive in reaching the primary endpoint [PFS by independent review], and pirtobrutinib was better than the control arm,” said Mazyar Shadman, MD, of Fred Hutch Cancer Center in Seattle, who was not involved in this study. Dr Mazyar Shadman called the PFS results “a little bit disappointing” because the phase 1/2 BRUIN trial (NCT03740529) “showed a better response” with pirtobrutinib. He noted, however, that BRUIN CLL-321 “enrolled heavily pretreated, very high-risk patients, and the time to next treatment looks better.” The median time to next treatment or death was 24.0 months in the pirtobrutinib arm and 10.9 months in the investigator’s choice arm (HR, 0.37; 95% CI, 0.25-0.52; P P “The study also had a crossover built in, so patients randomized to the control arm initially could get pirtobrutinib,” Dr Mazyar Shadman pointed out. “There was no overall survival difference, but

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Trial results presented at the ASH Annual Meeting 2024 could prompt changes in the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), experts say.Results from the phase 3 BRUIN CLL-321 trial showed that pirtobrutinib improved outcomes over investigator’s choice of therapy in CLL/SLL patients who had received prior treatment with a covalent BTK inhibitor.1 The findings could lead to the approval of pirtobrutinib as a second-line treatment for these patients, according to one expert. Results from the phase 3 AMPLIFY trial showed that fixed-duration acalabrutinib plus venetoclax, with or without obinutuzumab, improved survival outcomes when compared to chemoimmunotherapy in patients with treatment-naïve CLL.2 These findings could support a new approval as well, another expert said.Long-term follow-up data from 2 trials revealed that chimeric antigen receptor (CAR) T-cell therapy, with or without ibrutinib, can produce durable responses in patients with relapsed or refractory CLL.3 The results suggest a potential for cure, according to the study presenter.And results from the phase 2 HOVON 158/NEXT STEP trial suggested that minimal residual disease (MRD) and response assessment can be used to guide treatment intensification in patients with CLL.4BRUIN CLL-321: Pirtobrutinib vs Investigator’s Choice BRUIN CLL-321 is the first randomized, phase 3 trial assessing the safety and efficacy of treatment in patients who were previously treated with a covalent BTK inhibitor, said Jeff Sharman, MD, of Willamette Valley Cancer Institute in Eugene, Oregon, who presented the trial results at ASH 2024.1 The trial (NCT04666038) showed that pirtobrutinib improved progression-free survival (PFS), event-free

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